The correct combination of COOLGLIDE laser and SOLERA light laser is applied to the skin over your spider veins. Laser energy causes your spider veins to coagulate and shrink. Laser therapy is most effective for small and medium size spider veins. Treatments are associated with mild discomfort, not unlike a small rubber band snapping against skin. Treatments do not require sedatives, pain medications, or injections of local anesthetic.. After each treatment, you will see a 70% to 80% improvement to reduce the red and purplish veins. An average of three treatments will be required at three-month intervals.